Rejuran is a skin‑regeneration injectable using salmon‑derived polynucleotides (PN) to stimulate collagen, improve skin elasticity, and repair damage. Widely offered in Malaysian aesthetic clinics, it supports skin texture, pore size, fine lines, and hydration with minimal downtime. Multiple sessions yield gradual, natural rejuvenation.
What Is Rejuran?
Active Ingredient: Polynucleotides (PN), derived from highly purified salmon DNA.
Mechanism: PN molecules activate fibroblasts in the dermis, triggering collagen, elastin, and extracellular matrix regeneration.
Forms / Variants:
Rejuran Healer (classic): for overall skin regeneration.
Rejuran i: lighter formulation for delicate or thin skin (e.g., under‑eyes).
Rejuran s: designed for scarred or depressed areas.
Rejuran HB+: includes lidocaine for more comfortable injections.
Symptoms / Skin Concerns Treated by Rejuran
Rejuran is typically used to address:
Poor skin elasticity or sagging
Fine lines and wrinkles
Enlarged pores
Sun-damaged or photo-aged skin
Acne scars or depressed scars
Skin dryness, dullness, or uneven tone
Thin or atrophic skin (e.g., hands, neck)
Causes / Rationale for Use
Ageing: As we age, fibroblast activity declines, reducing collagen and elastin; PN helps “wake up” cells.
Skin Damage: UV exposure, inflammation, or injuries degrade the extracellular matrix; PN supports repair.
Poor Skin Barrier: Rejuran can restore the skin’s structural foundation and improve hydration balance.
Scarring: The regenerative effect of PN helps remodel scar tissue.
Diagnosis / Assessment Before Treatment
Before a clinician administers Rejuran:
Medical Consultation: Review medical history, skin conditions, allergies.
Skin Assessment: Examine skin type, texture, laxity, and identify target areas.
Patch Test or Safety Discussion: Though PN is biocompatible, a discussion about risks and expectations is performed.
Treatment Planning: Decide on variant (Healer, i, s, HB+), number of sessions, injection technique.
Treatment Options & Procedure
Technique: Micro‑injections (mesotherapy) into superficial to mid dermis.
Anesthesia: Topical numbing cream may be applied to reduce discomfort.
Session Duration: Usually 10–15 minutes for full face or targeted region.
Course: Typically 2–4 sessions, spaced 3–4 weeks apart, though protocols vary.
Combination: Can be combined with other aesthetic treatments (e.g., fillers, botulinum toxin, threads) for synergistic effects.
Risks & Side Effects
While Rejuran is generally safe, possible side effects include:
Redness, swelling, or warmth at injection sites
Small bumps (“meso bumps”) lasting 1–2 days
Bruising at injection sites
Mild itching or discomfort
Rare risk of infection if proper sterility or aftercare is not followed
Safety Profile:
PN is highly biocompatible because salmon-derived DNA is structurally similar to human DNA.
No immune response or allergic reaction typical in well-purified PN.
Avoid in pregnancy or unsettled skin disease; special consultation required.
Prevention & Aftercare
To maximize results and reduce risks:
Post‑Treatment Care:
Avoid strong physical activity, saunas, or hot baths for ~24 hours
Apply gentle skincare; avoid harsh exfoliants for several days
Use broad-spectrum sunscreen daily to protect regenerating skin.
Maintenance:
After initial series, consider maintenance injections every 4–6 months, or as advised by your clinician.
Clinic Safety:
Choose a reputable, licensed aesthetic clinic.
Verify the authenticity of the product packaging (some users report fakes).
When to See a Doctor
You should consult your physician / dermatologist if:
You experience prolonged or worsening redness, swelling, or pain beyond a few days.
You develop signs of infection (fever, pus, heat).
You have a history of allergic reactions to injectables or biologic materials.
You are pregnant or breastfeeding (safety not fully studied).
You are undergoing other skin treatments and are unsure about combining them.
Benefits of Rejuran Treatment (Why It’s Popular in Malaysia)
Non‑surgical skin rejuvenation with low downtime, making it suitable for busy professionals.
Natural-looking improvement rather than volume filling — ideal for skin quality over contour.
Regenerates from within: boosts collagen and skin structure rather than just hydration.
Good safety profile with biocompatible material.
Versatile: treat face, neck, hands, delicate area (under-eyes), post-acne scarring.
Frequently Asked Questions (FAQ)
Q1: Is Rejuran safe for all skin types?
Yes — because PN is derived from salmon DNA and highly purified, it is well‑tolerated by most skin types. However, you should still consult a licensed doctor for personalized evaluation.
Q2: How many treatments do I need?
Typically, 2–4 sessions, spaced 3–4 weeks apart, are recommended for optimal results. After that, maintenance every 4–6 months may help.
Q3: When will I see results?
Improvements begin within 1–2 weeks, but full collagen and skin-structure results often become more visible over 4–6 weeks.
Q4: Does it hurt?
Discomfort is usually mild. Clinics often apply a numbing cream before micro-injections to reduce pain.
Q5: How long do the effects last?
Results from a full course may last several months, but this varies by skin condition, age, and maintenance. Many clinics recommend a maintenance session every 4–6 months.
Q6: Can Rejuran replace dermal fillers?
Not exactly. Rejuran regenerates skin by stimulating collagen, but it does not “fill” like hyaluronic acid fillers. For volume restoration, fillers may still be needed.
Q7: Is Rejuran legal and regulated in Malaysia?
Yes — many licensed aesthetic clinics in Malaysia (KKM‑compliant) offer Rejuran treatments. Always confirm clinic credentials and product authenticity.
Q8: Are there any long-term risks?
Long-term risks appear low based on current evidence. PN is biocompatible, and adverse reactions are typically mild and transient.