Thinking about getting that famous “Salmon DNA Injections” glow? While Rejuran Healer is a hit in Kuala Lumpur for its regenerative powers, being aware of Rejuran side effects is essential. Understanding what to expect helps you prepare for a smooth recovery and achieve that flawless glass skin.
GLOJAS Specialist Clinic provides a safe rejuran treatment performed by LCP-certified doctors. Our medical-grade protocols ensure optimal skin regeneration with minimal downtime for every patient.
What is Rejuran Treatment?
Rejuran is an injectable skin booster consisting of Polynucleotides (PN), which are biological molecules harvested from salmon DNA. Unlike traditional fillers, it focuses on cellular repair. It is widely used in Malaysia to treat acne scars, enlarged pores, and aging skin by improving overall skin density.
How Rejuran Works on the Skin (PDRN Skin Repair Mechanism)
The Polynucleotides in Rejuran trigger the body’s natural healing response. By stimulating fibroblast activity, it increases collagen production and repairs damaged DNA. This biological “reset” thickens the dermis, providing a structural lift and better hydration without the use of synthetic chemicals.
Common Rejuran Side Effects
Most side effects are mild and temporary, usually resolving within a few days. Because Rejuran involves micro-injections, your skin will naturally react to the physical “trauma” of the needle. Here is a breakdown of what most patients in Malaysia experience:
Redness and Swelling After Injection
Immediately after the procedure, you will notice small “mosquito bite” bumps (papules) across the treated area. This is the product sitting in the dermis. Mild redness and swelling are expected as your skin begins the absorption process, typically peaking within the first 24 hours.
Bruising at Injection Sites
Because the face is vascular, minor bruising can occur, especially around thin-skinned areas like the eyes. These tiny hematomas are usually pinpoint-sized. Using a topical vitamin K cream or avoiding blood thinners before your appointment can significantly minimize this common occurrence.
Mild Pain or Tenderness
While clinics use high-strength topical numbing cream, you may feel a slight stinging sensation during the injection. Afterward, the skin might feel tender or “tight” for a day or two. This is a sign of the inflammatory healing cascade beginning its work.
Temporary Skin Sensitivity
Your skin barrier is temporarily compromised after micro-injections. You might find that your usual skincare products sting slightly. It is best to stick to a minimalist routine involving only a gentle cleanser and a soothing, fragrance-free moisturizer for the first 48 hours.
Rare Rejuran Side Effects
While rare, more serious complications can occur, often due to improper technique or poor aftercare. Choosing an LCP-certified doctor in Malaysia is the best way to mitigate these risks.
Allergic Reactions
Although PN is highly biocompatible, rare allergic reactions to the protein components can occur. Symptoms include hives, intense itching, or severe swelling. If you have a known fish or salmon allergy, discuss this with your physician before proceeding with treatment.
Infection Risk at Injection Site
Any procedure that breaks the skin carries an infection risk. This usually manifests as increasing pain, heat, or yellow crusting. Maintaining a sterile environment during the procedure and following strict hygiene protocols at home is vital to prevent bacterial entry into the micro-channels.
Skin Lumps or Uneven Texture
In rare cases, lumps can persist if the product is injected too superficially or if the body forms a granuloma. While Rejuran papules usually disappear within 3 days, any persistent, hard lumps should be evaluated by your doctor for professional massage or resolution.
Prolonged Swelling
If swelling lasts longer than a week, it may indicate an inflammatory hypersensitivity. While standard swelling is manageable with cold compresses, prolonged edema requires medical intervention. This is why following Ministry of Health (MOH) Malaysia safety guidelines for aesthetic procedures is non-negotiable.
How Long Do Rejuran Side Effects Last?
| Symptom | Expected Duration |
| Injection Bumps (Papules) | 24 – 72 Hours |
| Redness | 1 – 2 Days |
| Mild Bruising | 3 – 7 Days |
| Tenderness | 24 – 48 Hours |
What Causes Rejuran Side Effects?
Side effects are primarily caused by the mechanical action of the needle and the volume of the product placed under the skin. The more “damaged” the skin is initially, the more intense the inflammatory response may be as the PN starts the repair process.
Who Is More Likely to Experience Side Effects?
Patients with naturally thin, sensitive skin or those prone to easy bruising are more likely to see visible marks. Additionally, those taking supplements like fish oil, Vitamin E, or blood-thinning medications may experience more significant bruising than the average patient.
Is Rejuran Safe for Skin Treatment?
Yes, Rejuran is considered very safe and is approved by the Medical Device Authority (MDA) in Malaysia. Because it is non-comedogenic and uses DNA fragments similar to our own, the risk of long-term adverse reactions is much lower than with traditional synthetic fillers.
How to Reduce Rejuran Side Effects
Before Treatment Precautions
To minimize bruising, avoid alcohol, aspirin, and anti-inflammatory drugs like Ibuprofen for at least 3 to 5 days before your session. Ensure your skin is free of active infections or cold sores. Staying well-hydrated also helps the skin recover faster from the micro-trauma.
Aftercare Instructions for Faster Recovery
Avoid strenuous exercise, saunas, and hot baths for at least 24 hours to prevent increased blood flow to the face, which can worsen swelling. Use a broad-spectrum sunscreen diligently, as your skin will be more photosensitive during the initial healing phase.
When to See a Doctor After Rejuran Treatment
You should contact your clinic immediately if you experience fever, pus at the injection sites, or if the initial papules begin to feel hot and painful rather than subsiding. Early intervention is key to managing rare complications like localized infections or vascular compromise.
Frequently Asked Questions About Rejuran Side Effects in Malaysia
Are Rejuran bumps normal?
Yes, the small bumps are completely normal. They represent the Rejuran gel deposited in the dermal layer. They typically flatten out within 24 to 48 hours as the product is absorbed and distributed throughout the skin.
Can I wear makeup after Rejuran?
It is recommended to wait at least 24 hours before applying makeup. This allows the injection points to close fully, reducing the risk of trapping bacteria or irritating the skin with cosmetic chemicals.
Is Rejuran safer than fillers?
Generally, yes. Rejuran is a “healer” rather than a “volumizer,” so it doesn’t carry the same risks of vascular occlusion or migration that hyaluronic acid fillers occasionally do. It is a regenerative treatment, not a structural one.