If you’ve been keeping an eye on the latest aesthetic trends, you’ve likely heard a name whispered in every high-end skin clinic: Profhilo. Often dubbed the “injectable glow,” it has carved out a unique niche in the world of skincare. But despite its popularity, there is often a bit of confusion—is it a filler? Is it a skin booster?
The answer lies in understanding how Profhilo works, a process scientifically known as bio-remodelling. Unlike traditional treatments that simply mask the signs of aging, Profhilo actually talks to your skin cells to encourage them to act younger. Let’s dive into the fascinating science behind this “honey-like” injectable.
5 Key Takeaways: How Profhilo Works
It’s a Bio-Remodeller, Not a Filler: Profhilo doesn’t add volume or change your facial shape; instead, it restructures aging and sagging tissue.
Ultra-High HA Concentration: It contains one of the highest concentrations of pure Hyaluronic Acid (HA) on the market (64mg per 2ml).
Dual-Action Hydration & Lifting: It provides a “Hydro” effect for deep hydration and a “Lift” effect by stimulating structural proteins.
Stimulates 4 Types of Collagen: Profhilo is clinically proven to trigger the production of four different types of collagen and elastin fibers.
The BAP Technique: It uses the Bio Aesthetic Points method—just 5 injection sites per side—to ensure the product spreads evenly across the entire face.
What Exactly is Bio-Remodelling?
To understand how Profhilo works, we first have to clear up the biggest myth: it is not a dermal filler. Dermal fillers are designed to stay in one place to create a physical “plug” that adds volume to lips or cheeks.
Bio-remodelling is different. Profhilo uses a patented technology called NAHYCO® to create “hybrid cooperative complexes” of both high and low molecular weight Hyaluronic Acid. Because it doesn’t use chemical cross-linking agents (like BDDE), the product has a unique, fluid consistency. Once injected, it doesn’t sit in a lump; it flows like honey through the subcutaneous layers, integrating into the skin’s architecture to remodel it from the inside out.
The Two-Step Biological Process
The “magic” of Profhilo happens in two distinct phases that transform the skin’s quality over several weeks.
Phase 1: The Deep Hydration “Bath”
Immediately after injection, the low molecular weight HA begins to bind with water. This provides a massive, “bath-like” hydration boost to the deeper layers of the dermis. Patients often report a “glass skin” glow within the first week as the skin’s moisture reservoir is replenished.
Phase 2: The Remodelling Phase
This is where the long-term benefits kick in. As the Profhilo remains in the skin for about 28 days, it acts as a bio-stimulator. It interacts with your fibroblasts (the cells that make collagen) and keratinocytes (the cells in your outer skin layer).
By “waking up” these cells, Profhilo induces the synthesis of:
Collagen Types I, II, III, and IV
Elastin
The result? Skin that is physically firmer, more elastic, and visibly lifted without the “overfilled” look associated with traditional injectables.
Why the BAP Technique is a Game Changer
One of the reasons people love Profhilo is the minimal downtime. Practitioners use the Bio Aesthetic Points (BAP) technique, which involves only five strategic injection points on each side of the face.
These points are chosen because they are “safe zones” away from major vessels and nerves, and they allow the product to diffuse optimally across the malar (cheek) and submalar areas. This means you get a full-face rejuvenation with fewer needle pokes and a lower risk of bruising.
Comparison: Profhilo vs. Traditional Fillers
| Feature | Profhilo (Bio-Remodeller) | Traditional Dermal Fillers |
| Primary Goal | Skin quality and hydration | Volume and contouring |
| Consistency | Fluid, spreads evenly | Gel-like, stays in place |
| Collagen Impact | Stimulates 4 types of collagen | Minimal to no stimulation |
| Appearance | Subtle, “natural” glow | Visible structural change |
| Treatment Areas | Face, neck, hands, chest | Lips, cheeks, jawline |
The Results Timeline: What to Expect
Profhilo is a “slow burn” treatment. While you might see a boost in radiance quickly, the real structural changes take time.
Week 1: Increased hydration and a subtle “fresh” look.
Week 4 (After Session 1): Improved skin texture and a reduction in “crepeyness.”
Week 8 (4 Weeks After Session 2): Peak results. This is when the bio-remodelling is in full swing, and you’ll notice the most significant lifting and firming.
To maintain these results, most experts recommend a maintenance session every six to nine months.
Frequently Asked Questions (FAQs)
Q: Does Profhilo hurt?
The injections may sting slightly for a few seconds due to the high concentration of HA, but the BAP technique keeps the number of injections low. Most patients find it very tolerable without numbing cream.
Q: Can I combine Profhilo with Botox?
Absolutely! In fact, many clinicians recommend it. While Botox relaxes muscles to stop wrinkles, Profhilo improves the quality of the skin sitting on top of those muscles.
Q: Are there any side effects?
The most common side effects are small, bee-sting-like bumps at the injection sites. Because Profhilo is highly fluid, these usually disappear within 4 to 24 hours as the product spreads.
Q: Who is the ideal candidate for Profhilo?
It is perfect for anyone over 30 who is starting to notice skin laxity, fine lines, or a “tired” complexion. It’s also a fantastic preventative treatment for younger skin.
Q: Is Profhilo safe?
Yes. Because it is made of ultrapure, natural Hyaluronic Acid and contains no chemical cross-linkers, it has a very high biocompatibility and a low risk of inflammatory reactions.
GLOJAS Specialist Clinic provides world-class bio-remodelling treatments, combining medical expertise with the latest HA technology to deliver a natural, youthful lift that radiates from within.