As the demand for regenerative aesthetic medicine in Malaysia continues to grow, traditional dermal fillers are no longer the only solution for facial rejuvenation. Patients today are seeking treatments that repair the skin at a cellular level, not just temporary volume.
Plenhyage XL, an advanced polynucleotide (PN) injectable from Italy, represents the next generation of skin rejuvenation. At GLOJAS Specialist Clinic in Kuala Lumpur, board-certified plastic surgeon Dr. Muya specializes in DNA-based regenerative injectables that restore skin quality, elasticity, and resilience—naturally.
What Is Plenhyage XL?
Plenhyage is a CE-marked polynucleotide gel derived from highly purified Salmon DNA (PDRN). Unlike Hyaluronic Acid (HA) dermal fillers that mechanically fill hollows, Plenhyage works as a biostimulator, activating the skin’s own repair mechanisms.
Once injected, polynucleotides act as biological “messengers” that stimulate fibroblasts to produce Type I collagen and elastin. This process—known as biorejuvenation—restructures the skin from within, improving thickness, elasticity, and texture over time.
Plenhyage is often referred to as a DNA skin booster or regenerative skin injectable, ideal for patients who want skin repair rather than facial reshaping.
Key Benefits of Plenhyage Polynucleotide Treatment
Cellular Skin Regeneration
Repairs damaged tissue
Improves skin thickness by up to 50%
Strengthens the dermal matrix
Acne Scar Treatment
Plenhyage XL / Strong (2.5% PN) is designed to remodel fibrotic scar tissue
Smooths depressed acne scars and improves skin texture
Under-Eye & Dark Circle Rejuvenation
Plenhyage Fine or Medium is ideal for the delicate periorbital area
Reduces hollows and dark circles
No Tyndall effect, unlike some HA fillers
Anti-Inflammatory & Skin-Calming Effects
Suitable for sensitive skin
Helps manage redness, rosacea, and post-inflammatory damage
Antioxidant & UV Protection
Acts as a free radical scavenger
Protects against Malaysia’s intense UV-related photoaging
The Three Variants of Plenhyage
Dr. Muya will recommend the appropriate formulation based on your skin condition and treatment goals:
Plenhyage Medium (2.0% PN) is recommended for patients with early signs of aging, fine lines, and mild under-eye hollows. It improves overall skin quality and elasticity, making it ideal for general facial rejuvenation and maintaining youthful skin texture.
Plenhyage Strong / XL (2.5% PN) is formulated for more advanced skin concerns such as deep wrinkles, acne scars, and significant loss of skin density. Its higher polynucleotide concentration supports intensive tissue repair and is suitable for areas including the face, neck, hands, and other body regions requiring deeper regeneration.
Plenhyage Skin Booster Formulation focuses primarily on hydration and skin radiance. It enhances skin luminosity, improves smoothness, and delivers a healthy “glass skin” appearance, making it ideal for patients seeking immediate glow alongside long-term skin revitalization.
Plenhyage Treatment in Kuala Lumpur at GLOJAS Specialist Clinic
At GLOJAS Clinic, we performed with precision and a deep understanding of facial anatomy, ensuring safe, effective, and natural-looking regenerative results under expert medical care.
Consultation begins with a comprehensive evaluation of your skin quality, laxity, scarring, and overall structural needs, allowing Dr. Muya to design a personalized treatment plan tailored to your concerns.
Injection Technique involves either micro-injections or cannula-based delivery to achieve even product distribution while minimizing bruising and discomfort, optimizing both safety and aesthetic outcomes.
Recommended Sessions typically consist of three treatments spaced 3–4 weeks apart to activate progressive skin regeneration, followed by a maintenance session every six months to sustain collagen production and results.
Downtime is minimal, with most patients experiencing only small injection-site bumps that resolve naturally within 24–48 hours, allowing a quick return to daily activities.
Plenhyage vs Dermal Fillers & Other Skin Boosters
Plenhyage is not a dermal filler. Unlike traditional HA fillers that add volume, Plenhyage works at a cellular level to improve skin quality, elasticity, and thickness. It stimulates fibroblasts to produce collagen and elastin, restoring the skin’s structure naturally. Results are gradual and long-lasting, focusing on rejuvenation rather than immediate volumization.
Plenhyage can also be combined with other aesthetic treatments for enhanced results. It works with Profhilo to boost hydration and radiance, complements Botox to smooth dynamic wrinkles, and can be paired with laser or energy-based therapies for skin resurfacing. This combination builds a strong cellular foundation, improving the longevity and effectiveness of subsequent treatments.
How Much Does Plenhyage Skin Booster Price in Malaysia?
Treatment pricing in Malaysia varies depending on whether you consider the product alone or a full medical procedure. Online listings may show RM500–RM570 per 2 ml box, but clinic treatments Plenhyage typically range from RM1,000 to RM2,000+ per session. Plenhyage is prescription-only, so professional assessment and expert injection are essential for safe, effective results.
Frequently Asked Questions (FAQs)
Is Plenhyage the same as a dermal filler?
No. Plenhyage is a polynucleotide biostimulator, not a filler. It stimulates collagen production and skin repair rather than altering facial shape.
How long do the results last?
Results are cumulative. After a full treatment course, effects typically last 9–18 months, with maintenance sessions recommended every 6 months.
Is Plenhyage safe for all skin types?
Yes. Plenhyage is highly biocompatible and suitable for all skin types, including sensitive and rosacea-prone skin.
Can Plenhyage treat acne scars effectively?
Yes. Plenhyage XL (Strong) is particularly effective for remodeling acne scars and improving uneven skin texture.
Why Choose GLOJAS Specialist Clinic?
GLOJAS Specialist Clinic is led by a board-certified plastic surgeon with international fellowship training, offering a high level of expertise in facial anatomy and regenerative aesthetics. As a KKM-accredited clinic in Malaysia, GLOJAS uses only authentic, CE-marked injectable products, ensuring both safety and efficacy.
Every treatment is carefully personalized and performed under medical-grade safety standards, allowing patients to achieve natural, refined results with confidence and trust.