Profhilo is an injectable bio-remodelling treatment that stimulates collagen and elastin production, improving skin elasticity, hydration, and firmness. Using stabilized hyaluronic acid, it spreads evenly under the skin, enhancing tissue quality and texture. Ideal for early signs of aging, Profhilo delivers natural-looking results with minimal downtime.
GLOJAS Specialist Clinic is a trusted leader in Profhilo treatments, combining clinical expertise with evidence-based protocols. Our board-certified clinicians deliver safe, effective skin bio-remodelling, stimulating collagen and improving elasticity for natural, long-lasting results, ensuring each patient achieves firmer, hydrated, and rejuvenated skin with minimal downtime.
Introduction
Skin aging is characterized by reduced collagen and elastin, causing sagging, fine lines, and loss of elasticity. Profhilo is a next-generation injectable treatment designed to remodel skin tissue and restore firmness. Unlike traditional dermal fillers, it does not volumize but enhances structural integrity through biostimulation.
Mechanism of Action
1. Hyaluronic Acid Delivery:
Profhilo contains ultra-pure, high-concentration hyaluronic acid (HA) at 64 mg/2 mL.
HA spreads evenly in the superficial subcutaneous layer, hydrating and supporting skin structure.
2. Biostimulation:
HA acts as a scaffold to stimulate fibroblasts.
Promotes production of Type I and III collagen and elastin fibers, essential for elasticity and firmness.
3. Tissue Remodeling:
The slow, controlled release of HA triggers gradual tissue regeneration.
Improves dermal density, skin smoothness, and hydration over 4–8 weeks.
Indications for Profhilo
Profhilo is suitable for patients experiencing:
Early signs of facial aging (loss of elasticity, fine lines)
Dehydrated, dull, or crepey skin
Sagging in the lower face, jawline, and neck
Areas requiring subtle skin tightening without volumization
Popular treatment areas: face, neck, décolletage, hands, and arms.
Treatment Procedure
Step-by-Step Overview:
Consultation: Assessment of skin quality and elasticity.
Injection Technique: Five injection points per side of the face (BAP—Bio Aesthetic Points) to maximize even HA distribution.
Session Duration: Typically 30 minutes.
Post-Treatment Care: Minimal downtime; mild swelling or redness may occur for 24–48 hours.
Sessions: Usually 2 sessions spaced 4 weeks apart; maintenance every 6–12 months.
Clinical Efficacy
Collagen & Elastin Stimulation: Histological studies show increased fibroblast activity and collagen types I & III after treatment.
Hydration & Elasticity: HA improves water retention, plumping skin and reducing fine lines.
Patient Outcomes: Most patients report firmer, smoother, and more radiant skin after 4–8 weeks.
Evidence: Multiple peer-reviewed studies support Profhilo’s bio-remodelling effect, demonstrating improved dermal density, elasticity, and hydration with a high safety profile.
Safety Profile
Side Effects: Mild redness, swelling, or tenderness; typically resolves within 1–2 days.
Contraindications: Pregnancy, lactation, active skin infections, hypersensitivity to HA.
Long-Term Safety: Well-tolerated; no evidence of tissue damage or nodule formation.
Advantages Over Traditional Fillers
| Feature | Profhilo | Dermal Fillers |
|---|---|---|
| Purpose | Skin bio-remodelling | Volumization |
| Collagen Stimulation | High | Moderate |
| Hydration | Excellent | Moderate |
| Downtime | Minimal | Variable |
| Natural Results | Yes | Can be volumizing |
Profhilo is ideal for patients seeking subtle, natural improvement in skin texture and elasticity rather than contour correction.
Patient Experience
Pain Level: Mild; topical anesthetic optional.
Downtime: Minimal; most return to normal activities immediately.
Visible Results: Skin texture, hydration, and elasticity improve gradually over 4–8 weeks.
Longevity: Results typically last 6–12 months; maintenance sessions prolong benefits.
Combination Treatments
Profhilo can be combined safely with:
Botulinum toxin: For dynamic lines and facial rejuvenation.
Dermal fillers: For volume restoration in cheeks, chin, or jawline.
Laser or microneedling treatments: To enhance skin texture and collagen stimulation.
FAQs
Q1: How does Profhilo differ from dermal fillers?
A: Profhilo remodels and hydrates the skin by stimulating collagen and elastin without adding volume, unlike fillers that physically lift or contour.
Q2: Is Profhilo safe for all skin types?
A: Yes, it is well-tolerated across all Fitzpatrick skin types, with minimal risk of hyperpigmentation or adverse reactions.
Q3: How soon will I see results?
A: Gradual improvement occurs over 4–8 weeks as collagen and elastin production increases, with optimal results after two sessions.
Q4: Does Profhilo hurt?
A: Discomfort is minimal; most patients report only mild tingling or pressure at injection sites.
Q5: How long do results last?
A: Benefits last approximately 6–12 months; maintenance treatments help sustain collagen stimulation and skin elasticity.
Q6: Can Profhilo be used on the neck or hands?
A: Yes, it is effective for improving skin quality in delicate areas like the neck, décolletage, and hands.
Q7: Are there any side effects?
A: Side effects are mild and temporary, including redness, swelling, or tenderness that usually resolves within 1–2 days.
Conclusion
Profhilo is a scientifically validated, minimally invasive solution for improving skin elasticity, hydration, and collagen production. By stimulating fibroblasts and enhancing tissue quality, it delivers natural, gradual rejuvenation with minimal downtime. Ideal for early aging signs, Profhilo restores firmness, smoothness, and radiance safely and effectively.