If you’re researching skin boosters, chances are you’ve come across Plenhyage and Rejuran. Both are popular injectable treatments designed to improve skin quality, texture, and overall health—but they work in very different ways.
So which one is better?
The short answer: it depends on your skin goals.
Let’s break down Plenhyage vs Rejuran in simple terms so you can decide which treatment makes the most sense for your skin.
Overview of Plenhyage and Rejuran
What Is Plenhyage?
Plenhyage is a next-generation skin booster that combines high-concentration hyaluronic acid (HA) with polynucleotides (PN). This powerful combo focuses on:
Deep hydration
Skin regeneration
Improved elasticity and glow
Plenhyage is often described as a skin quality enhancer rather than a filler—it won’t add volume but will make your skin look healthier and more youthful.
What Is Rejuran?
Rejuran is a well-known polynucleotide (PN/PDRN) injectable, derived from salmon DNA. It’s famous for its ability to:
Repair damaged skin
Strengthen the skin barrier
Improve skin texture from within
Rejuran is especially popular for acne scars, sensitive skin, and post-procedure healing.
Key Differences at a Glance
Plenhyage = hydration + regeneration
Rejuran = deep skin repair and healing
Plenhyage gives faster “glow” results
Rejuran works more slowly but deeply
Key Ingredients and How They Work
Plenhyage Ingredients and Mechanism of Action
Plenhyage contains:
High molecular weight hyaluronic acid for hydration and plumpness
Polynucleotides (PN) to stimulate skin repair and collagen production
This combination improves skin quality on multiple levels—hydrating the surface while regenerating skin cells underneath.
Rejuran (PN/PDRN) Ingredients and Mechanism of Action
Rejuran’s star ingredient is polynucleotides, which:
Stimulate fibroblasts (collagen-producing cells)
Repair damaged or inflamed skin
Improve skin thickness and resilience
It focuses less on hydration and more on healing and rebuilding.
How Each Treatment Stimulates Skin Regeneration
Plenhyage boosts hydration and cell turnover simultaneously
Rejuran activates long-term skin repair at a cellular level
Think of Plenhyage as a skin refresh, and Rejuran as a skin rehab program.
Benefits of Plenhyage vs Rejuran
Benefits of Plenhyage for Skin Quality
Deep hydration
Improved skin glow
Smoother texture
Better elasticity
Fresher, more youthful appearance
Great if your skin looks tired, dull, or dehydrated.
Benefits of Rejuran for Skin Healing and Repair
Repairs acne-damaged skin
Strengthens weak or sensitive skin
Improves fine lines over time
Reduces inflammation
Ideal for skin that needs repair more than hydration.
Which Treatment Delivers Better Anti-Aging Results?
Plenhyage: quicker visible improvement
Rejuran: slower but longer-lasting structural improvement
Many clinics actually recommend combining both for optimal anti-aging.
Plenhyage vs Rejuran for Different Skin Concerns
Acne Scars and Damaged Skin
Winner: Rejuran
Its regenerative properties make it better for acne scars and compromised skin.
Fine Lines, Wrinkles, and Elasticity
Winner: Plenhyage
Thanks to hyaluronic acid, Plenhyage gives better plumping and smoothing effects.
Dull, Dehydrated, or Sensitive Skin
Dull & dehydrated → Plenhyage
Sensitive or inflamed → Rejuran
Post-Procedure Skin Recovery
Rejuran is often used after lasers, microneedling, or peels to speed up healing.
Treatment Experience and Procedure Comparison
Injection Technique and Treatment Areas
Both treatments are injected using:
Microinjections
Mesotherapy techniques
Common areas include:
Face
Neck
Under-eyes
Hands
Pain Level and Downtime
Plenhyage: mild discomfort, minimal downtime
Rejuran: more stinging during injection, slightly longer downtime
Redness and small bumps usually settle within a few days.
Number of Sessions Required
Plenhyage: 2–3 sessions
Rejuran: 3–4 sessions
Sessions are typically spaced 2–4 weeks apart.
Results and Longevity
When You Can Expect to See Results
Plenhyage: glow and hydration within 1–2 weeks
Rejuran: gradual improvement over 3–6 weeks
How Long Plenhyage Results Last
Results typically last 4–6 months, depending on skin type and lifestyle.
How Long Rejuran Results Last
Rejuran results can last 6–12 months, especially after a full treatment course.
Side Effects and Safety Profile
Common Side Effects of Plenhyage
Mild swelling
Redness
Small injection bumps
Common Side Effects of Rejuran
Swelling
Bruising
Temporary tenderness
Which Is Safer for Sensitive Skin?
Both are safe when performed by a trained professional, but Rejuran is often preferred for sensitive or damaged skin due to its healing properties.
Plenhyage vs Rejuran: Cost and Value Comparison
Average Cost of Plenhyage Treatment
Plenhyage is usually slightly more expensive per session due to its dual-action formula.
Average Cost of Rejuran Treatment
Rejuran may be cheaper per session, but more sessions are often required.
Which Treatment Offers Better Value for Money?
Want faster glow → Plenhyage
Want long-term skin repair → Rejuran
Value really depends on your skin goals.
Which Is Better: Plenhyage or Rejuran?
Best Choice for Skin Rejuvenation
Plenhyage is ideal if your goal is brighter, smoother, well-hydrated skin.
Best Choice for Skin Repair and Healing
Rejuran is better for acne scars, sensitive skin, and long-term skin strengthening.
Dermatologist Recommendations
Many dermatologists recommend alternating or combining Plenhyage and Rejuran for comprehensive skin rejuvenation—hydration plus repair.
FAQs About Plenhyage vs Rejuran
Can Plenhyage and Rejuran Be Combined?
Yes. Combining them can deliver both immediate glow and long-term skin repair.
Which Treatment Is Better for Long-Term Skin Health?
Rejuran focuses more on structural repair, while Plenhyage maintains hydration and elasticity.
Who Is an Ideal Candidate for Each Treatment?
Plenhyage: dull, dry, aging skin
Rejuran: acne scars, sensitive, damaged skin
Final Thoughts
When it comes to Plenhyage vs Rejuran, there’s no one-size-fits-all answer. The best choice depends on whether your skin needs hydration and glow or repair and regeneration.