How Polynucleotides Repair Skin: The Science Behind PN Treatments

Polynucleotides (PN) are naturally derived molecules that have transformed modern skin rejuvenation. Found in advanced treatments like Rejuran Healer, they promote deep repair, hydration, and cell regeneration. Unlike conventional skincare that works mainly on the surface, PN treatments stimulate your skin’s innate ability to heal, strengthen the extracellular matrix, and improve elasticity. This makes them highly effective for addressing fine lines, uneven texture, and overall skin quality, providing a natural, healthy glow from the inside out.

What Are Polynucleotides and How Do They Work?

Polynucleotides are long chains of nucleotides, which are the building blocks of DNA and RNA. When applied topically or through injections like Rejuran Healer, they act as biological signaling molecules, triggering multiple regenerative processes in the skin.

How PN Supports Skin Repair:

1. Boosts Fibroblast Activity – Fibroblasts are cells responsible for producing collagen and elastin. Polynucleotides stimulate them to create stronger, more resilient skin.
2. Enhances Hydration – PN molecules improve water retention in the extracellular matrix, keeping skin plump and hydrated.
3. Reduces Inflammation – PN can calm irritation and support natural repair processes.
4. Improves Skin Elasticity & Texture – Over time, regular treatments enhance skin resilience and smoothness.

Because PN works at a cellular level, it addresses the root cause of ageing and damaged skin, rather than just masking it.

Why Rejuran Healer Is a Game-Changer

Rejuran Healer is a polynucleotides (PN)-based injectable treatment that has become highly popular for its anti-aging and regenerative effects. Unlike traditional dermal fillers, which mainly add volume, Rejuran focuses on enhancing the skin’s overall quality from within, targeting the root causes of ageing and skin damage.

Here’s what makes it unique:

• Stimulates natural collagen and elastin production
  Rejuran encourages your skin to regenerate at a cellular level, improving firmness, elasticity, and overall texture over time.

• Boosts hydration and strengthens the skin barrier
  By replenishing moisture and supporting the skin’s protective layer, Rejuran helps maintain plump, healthy skin that resists environmental stressors.

• Reduces redness and minor pigmentation issues
  Its healing properties calm inflamed skin, helping to even out tone and reduce dullness or blotchiness.

• Safe for virtually all skin types
  Biocompatible and gentle, it is suitable even for sensitive or reactive skin.

• Minimal downtime
  Most people can resume daily activities immediately, with only slight temporary redness or swelling at the injection site.

Because Rejuran works in harmony with your skin’s natural healing mechanisms, the results are subtle, natural, and long-lasting, giving you a refreshed, youthful appearance without the “overdone” look.

What Skin Concerns Can Polynucleotides Address?

Polynucleotides (PN) therapy is a versatile treatment that works at the cellular level to repair, regenerate, and rejuvenate the skin. It is effective for a wide range of skin concerns, including:

• Fine lines and early wrinkles
  PN stimulates collagen and elastin production, helping to soften the appearance of lines before they deepen.

• Dull, tired-looking skin
  By promoting cellular renewal, PN restores radiance and a healthy, youthful glow.

• Skin texture irregularities
  It smooths rough or uneven areas, improving overall skin refinement.

• Enlarged pores
  Strengthening the skin structure around pores helps them appear smaller and less noticeable.

• Mild scarring or acne scars
  PN encourages tissue repair, reducing the visibility of minor scars over time.

• Sensitive or reactive skin
  Its gentle, biocompatible nature makes PN suitable for skin prone to redness or irritation.

• Skin prone to inflammation
  PN supports skin barrier recovery and reduces oxidative stress, helping calm stressed skin.

Essentially, any concern related to early signs of ageing, minor damage, or skin stress can benefit from PN therapy. Regular sessions help maintain healthy, resilient, and naturally radiant skin.

The Science Behind Polynucleotides Skin Repair

PN molecules are highly biocompatible and work synergistically with the body’s natural repair processes. When injected:

1. Fibroblast Activation – The main driver of collagen regeneration.
2. Extracellular Matrix Strengthening – Improves skin’s structural integrity.
3. Enhanced Blood Flow – Promotes nutrient delivery and cellular repair.
4. Antioxidant Protection – Reduces oxidative stress that accelerates ageing.

The result is smoother, more elastic, and hydrated skin with improved resilience against environmental damage.

How Polynucleotides Differ From Other Anti-Aging Treatments

PN therapy is particularly suitable for people who want healthy, radiant skin without changing their natural facial features.

Treatment Process: What to Expect with Rejuran Healer

Undergoing Rejuran Healer is a straightforward and well-tolerated procedure. Here’s a step-by-step overview of what you can expect:

1. Consultation – Personalized Skin Assessment
   Your practitioner will evaluate your skin type, concerns, and suitability for PN therapy. This step ensures the treatment plan is tailored to your individual needs and desired outcomes.

2. Preparation – Cleansing and Numbing
   The treatment area is thoroughly cleansed to remove impurities. A numbing cream is applied to ensure maximum comfort during the injections.

3. Injection – Targeted Microinjections
   Using fine needles, Rejuran is injected into specific areas of the face, neck, or other targeted regions. The microinjections stimulate skin regeneration, collagen production, and hydration from within.

4. Immediate Care – Soothing and Hydration
   After injections, gentle soothing techniques and hydrating products are applied to calm the skin and enhance comfort.

5. Recovery – Minimal Downtime
   Most patients experience only mild redness, swelling, or tiny pinpoint marks at the injection sites, which typically resolve within a few hours to a couple of days. Daily activities can usually be resumed immediately.

6. Results Timeline – Gradual, Natural Improvement
   Rejuran works by stimulating the skin’s natural repair mechanisms. Improvements in texture, hydration, and firmness appear gradually over several weeks, with optimal results typically visible around 4–6 weeks post-treatment. Subtle, natural rejuvenation continues over the following months.

Benefits of Regular Polynucleotides Treatments

Consistent PN treatments offer long-term improvements in overall skin health, thanks to their ability to repair, hydrate, and strengthen the skin from within. Key benefits include:

• Stronger, more resilient skin
  PN helps repair damaged cells and boosts tissue regeneration, making the skin more robust against environmental stressors and ageing.

• Reduction in fine lines and early wrinkles
  By stimulating fibroblasts and encouraging collagen production, PN gradually softens early signs of ageing.

• Improved skin tone and texture
  Skin becomes smoother, more even, and more refined as cell turnover increases and micro-damage is repaired.

• Enhanced hydration and barrier function
  PN attracts and retains moisture while strengthening the skin barrier, leading to plumper, healthier-looking skin.

• Natural-looking rejuvenation
  Results are subtle and progressive, giving you fresher, more youthful skin without an overly “done” appearance.

• Suitable even for sensitive skin
  PN is gentle and biocompatible, making it well-tolerated by individuals prone to irritation or redness.

With consistent sessions, PN therapy can help maintain high-quality skin, support long-term regeneration, and slow down visible signs of ageing over time.

Who Is an Ideal Candidate for Polynucleotides Therapy?

Polynucleotide therapy is suitable for a wide range of individuals looking to improve overall skin quality. You may be an ideal candidate if you:

• Are aged 25 and above and starting to notice early signs of ageing such as fine lines, dryness, or loss of glow.

• Have dull, tired, or dehydrated skin that lacks radiance and elasticity.

• Struggle with mild texture concerns, including roughness, enlarged pores, or uneven tone.

• Prefer natural-looking results, as PN supports your own skin’s healing and regeneration rather than adding volume.

• Want preventive, early intervention skincare to slow down ageing changes before they become more prominent.

• Are recovering from aesthetic procedures like lasers, chemical peels, or microneedling and want enhanced healing and improved outcomes.

PN therapy is generally safe for most skin types and skin tones, thanks to its bio-compatible formulation. However, it should always be administered by a trained and licensed medical professional to ensure proper technique, safety, and optimal results.

How Many Sessions Are Needed?

Most people achieve the best results with a series of 3 sessions, usually spaced 4 weeks apart. This allows the skin enough time to heal and stimulate new collagen between treatments.

After completing the initial course, maintenance sessions every 6–12 months are recommended to keep the skin firm, smooth, and healthy.

Improvements develop gradually over several weeks, as your skin naturally regenerates from within. This slow, steady process ensures that the results look subtle, natural, and not overdone.

Frequently Asked Questions (FAQs)

1. What are polynucleotides in skincare?

Polynucleotides are natural DNA fragments that stimulate cell regeneration and collagen production.

2. Is Rejuran Healer painful?

Most people experience minimal discomfort; numbing cream is used for comfort.

3. How long before I see results?

Initial hydration and glow appear within a few days; collagen improvements are noticeable in 4–6 weeks.

4. Are there side effects?

Mild redness, swelling, or tiny bruises may occur but resolve within a few days.

5. Can Polynucleotides be combined with other treatments?

Yes—PN therapy works well with laser treatments, microneedling, and bioremodeling.

6. How long do results last?

Improvements last several months; maintenance sessions keep skin quality at its best.

7. Can sensitive skin undergo PN therapy?

Yes. PN is gentle and suitable for most skin types, including sensitive skin.

8. Is it safe for younger patients?

Yes, it’s often used preventively in late 20s to maintain skin health.

9. How is PN different from hyaluronic acid?

HA hydrates and plumps; PN regenerates and repairs skin at a cellular level.

10. Can it treat acne scars?

Yes, PN supports skin repair and improves minor scars and texture irregularities.

Conclusion

Polynucleotides offer a revolutionary approach to skin repair and rejuvenation, improving hydration, collagen production, and overall skin resilience. Treatments like Rejuran Healer help restore healthy, youthful skin without altering your natural features, making them ideal for both preventive and corrective care.