Polynucleotide treatment uses purified DNA fragments to repair skin, improve hydration, and support natural regeneration. It enhances collagen production, strengthens the skin barrier, and reduces inflammation. This scientifically backed therapy is commonly used for aging skin, acne scars, under-eye concerns, and overall skin rejuvenation with minimal downtime.
What Are Polynucleotides? (Definition)
Polynucleotides are biocompatible DNA fragments extracted from purified sources such as salmon or trout. These molecules act as regenerative bio-stimulators, helping the skin repair damage, regulate inflammation, and enhance hydration. They stimulate fibroblast activity, improve tissue healing, and support long-term skin quality without altering facial structure.
How Polynucleotides Work (Mechanism of Action)
Polynucleotides deliver regenerative benefits through multiple biological pathways:
Cell repair stimulation: Activate fibroblasts to produce collagen and elastin.
Deep hydration: Bind water molecules within the dermis, improving elasticity.
Anti-inflammatory effect: Reduce oxidative stress and soothe sensitive or compromised skin.
Tissue regeneration: Improve microcirculation and promote natural wound healing.
These actions make polynucleotides suitable for aging, dehydrated, acne-scarred, and fatigued skin.
Common Skin Concerns Treated With Polynucleotides
Fine lines and early aging
Loss of firmness or elasticity
Dull, dehydrated skin
Under-eye hollowness and dark circles
Atrophic acne scars
Redness or inflammation
Compromised skin barrier
Overall rejuvenation for tired or stressed skin
Causes of Skin Aging and Damage (Why Polynucleotides Help)
Skin changes occur due to internal and external factors:
Intrinsic aging: Decline in collagen and elastin production.
Sun exposure: UV radiation accelerates pigmentation and breakdown of structural proteins.
Environmental exposure: Pollution increases oxidative stress.
Lifestyle factors: Poor sleep, dehydration, smoking.
Inflammation: Acne or irritation weakens the skin barrier.
Polynucleotides help counter these processes by repairing inflammation-related injury and improving cellular function.
Diagnosis: How Doctors Determine If Polynucleotides Are Suitable
A clinician evaluates the skin using:
Full skin assessment for texture, elasticity, hydration, and barrier health
Medical history review to identify sensitivity, allergies, or contraindications
Evaluation of treatment goals (hydration, firmness, brightening, scar improvement)
Imaging tools such as dermoscopy or skin analysis scanners, if needed
Most patients with mild to moderate aging signs, dryness, scarring, or dullness are suitable candidates.
Treatment Options and Procedure Overview
1. Polynucleotide Injections (Most Common)
Administered into the superficial to mid dermis.
Uses microdroplet or linear threading technique.
Improves hydration, elasticity, and regenerative activity.
Typically performed in 15–20 minutes.
2. Polynucleotide for Under-Eyes
Targets dark circles, puffiness, volume loss, and thin under-eye skin.
Reduces inflammation and strengthens delicate tissue.
3. Polynucleotide for Acne Scars
Enhances tissue remodeling and improves atrophic scars.
Often combined with microneedling for stronger results.
4. Combination Treatments
Clinicians may combine polynucleotides with:
Skin boosters (non-crosslinked hyaluronic acid)
Microneedling
Laser resurfacing
Chemical peels
This layered approach supports comprehensive skin rejuvenation.
Treatment Course
Usually 2–4 sessions, spaced 2–4 weeks apart.
Maintenance every 6–9 months depending on skin condition.
Risks and Side Effects
Polynucleotides are generally safe and well-tolerated. Temporary effects include:
Mild redness
Small injection bumps
Tenderness
Slight bruising
Rare complications:
Allergic reaction
Persistent swelling or nodules
Infection at injection site
All procedures should be performed by trained medical professionals.
Benefits of Polynucleotides
Deep, long-lasting hydration
Improved collagen and elastin support
Smoother, firmer skin texture
Better skin repair response
Reduced inflammation and redness
Suitable for sensitive or post-procedure skin
Natural-looking results without altering facial shape
These advantages make polynucleotides a strong choice for patients seeking regenerative therapy.
Treatments That Use Polynucleotides (PN Brands Included)
Rejuran Healer
A PN-based regenerative treatment that improves skin repair, hydration, texture, and inflammation. Popular for under-eyes, fine lines, and overall rejuvenation.Rejuran I (Under-Eye PN)
Designed specifically for thin under-eye skin to reduce dark circles, fine wrinkles, and dryness with minimal downtime.Rejuran S (Scar PN)
Formulated for acne scars; promotes collagen remodeling and enhances scar healing, often used with microneedling.Plinest Polynucleotide
A PN-HPT (Highly Purified Technology) formulation that enhances skin elasticity, hydration, and regenerative ability, suitable for aging or dehydrated skin.Newest PN Booster
A dual-action PN + HA treatment that delivers hydration while stimulating collagen and tissue repair.S-DNA (Salmon DNA Therapy)
A polynucleotide treatment used for overall skin rejuvenation, strengthening, and anti-inflammatory repair.Pro-PRDN PN Therapy
A high-purity PN designed to improve skin density, texture, and elasticity while supporting long-term tissue regeneration.PN for Scalp & Hair Support
Polynucleotide formulations (e.g., PN-Scalp, Rejuran HB) promote scalp hydration, microcirculation, and healthier hair growth.PN for Neck, Hands & Décolletage
Used to restore elasticity, reduce crepiness, and improve thin, aging skin in sun-exposed areas.
Prevention: How to Maintain Skin Health After Treatment
Use daily sunscreen SPF 30–50
Maintain hydration with barrier-strengthening moisturizers
Avoid excessive sun exposure
Follow a consistent skincare routine
Reduce smoking and alcohol intake
Schedule maintenance treatments as advised
Preventive care helps preserve treatment results and improves long-term skin health.
When to See a Doctor
Consult a medical professional if you experience:
Persistent swelling beyond 72 hours
Increasing pain or redness
Signs of infection (fever, warmth, discharge)
Allergic reactions such as itching or difficulty breathing
Uncertain suitability due to medical conditions or pregnancy
Routine consultation is also recommended when exploring anti-aging or regenerative treatment options.
Frequently Asked Questions
1. Are polynucleotides the same as skin boosters?
No. Skin boosters provide hydration through hyaluronic acid. Polynucleotides stimulate repair, reduce inflammation, and improve tissue quality at a cellular level.
2. How soon can I see results?
Most patients notice improvements in hydration and smoothness within 1–2 weeks, with collagen-related benefits developing over the next months.
3. Do PN replace dermal fillers?
No. They restore skin quality but do not add significant volume. Fillers are still needed for structural contouring.
4. Are polynucleotides safe for sensitive skin?
Yes. Their anti-inflammatory nature makes them suitable for sensitive, thin, or compromised skin.
5. How long do the results last?
Results typically last 6–12 months, depending on skin condition, lifestyle, and maintenance.
6. Can polynucleotides be combined with lasers?
Yes. They are commonly used after lasers to accelerate healing and improve outcomes.
7. Are the injections painful?
Minor discomfort is expected. Most clinics apply topical numbing for comfort.
8. Can polynucleotides treat dark circles?
Yes. They improve hydration, microcirculation, and tissue thickness under the eyes, reducing dark circles and fatigue signs.
9. Who should avoid PN?
Patients with active infections, severe allergies, autoimmune disorders, or who are pregnant/breastfeeding should avoid treatment unless approved by a physician.
10. How many sessions do I need?
Typically 2–4 sessions spaced a few weeks apart for optimal regenerative benefits.