If you’ve been searching for the “secret sauce” to youthful, glass-like skin without the “frozen” look of traditional injectables, you’ve likely stumbled upon the latest buzzword in medical aesthetics: polynucleotides. Specifically, Plinest and Newest have emerged as the gold standard for regenerative skincare in 2026.
Unlike traditional fillers that simply add volume, these Italian-made bio-stimulators work at a cellular level to repair, hydrate, and renew your skin from the inside out.
GLOJAS Specialist Clinic provides expert Plinest and Newest treatments in Malaysia, leveraging 27 years of medical excellence to deliver regenerative, natural-looking skin rejuvenation through advanced polynucleotide technology.
Key Takeaways
Cellular Repair: Both treatments use Polynucleotide Highly Purified Technology (PN-HPT) to repair damaged DNA and stimulate collagen.
The Big Difference: Plinest is pure PN (best for repair/scars), while Newest adds Hyaluronic Acid (best for intense hydration).
Targeted Variations: Specific formulas like Plinest Hair and Plinest Fast (for eyes) allow for hyper-targeted rejuvenation.
Regenerative Synergy: These treatments are “force multipliers” when combined with lasers or microneedling.
Natural Evolution: Results peak over 3–6 months as your body builds its own “scaffolding,” lasting up to a year.
What are Plinest and Newest?
Plinest and Newest are injectable skin boosters developed by Mastelli, an Italian pharmaceutical pioneer. These treatments utilize polynucleotides (PN)—DNA fragments extracted from trout or salmon—to trigger a biological response in your skin cells.
While traditional skin boosters like Profhilo focus primarily on hydration via Hyaluronic Acid, Plinest and Newest are biorejuvenators. They don’t just “fill” a wrinkle; they signal your fibroblasts to produce fresh Type I collagen and elastin. This makes them a powerhouse for anyone dealing with “crepey” skin, fine lines, or sun damage.
The Science of PN-HPT™: How It Works
The secret lies in the PN-HPT (Polynucleotide Highly Purified Technology). When injected into the dermis, these molecules act like a “scaffold” for your skin.
Fibroblast Activation: They “wake up” the cells responsible for skin elasticity.
Water Binding: Polynucleotide chains are hydrophilic, meaning they suck in moisture to provide deep-tissue hydration.
Antioxidant Protection: They act as free-radical scavengers, protecting your skin from pollution and UV rays.
Wound Healing: These treatments are frequently used by specialists to treat acne scarring and chronic skin inflammation.
Plinest vs. Newest: Which One Do You Need?
Choosing between the two depends on your specific skin goals. Many practitioners use a “cocktail” approach, but here is the general breakdown:
Plinest (The Repair Specialist)
Plinest is the “pure” version, containing a high concentration of polynucleotides. It is the go-to choice for:
Atrophic Scars: Deep acne scars or stretch marks.
Skin Sagging: Areas where the skin has lost its “snap.”
Chronic Inflammation: Great for soothing rosacea-prone skin.
Newest (The Glow Master)
Newest combines the power of PN with Hyaluronic Acid (HA). This creates a synergistic effect that offers:
Instant Plumping: The HA provides an immediate “dewy” look.
Advanced Aging Support: Ideal for mature skin that feels chronically dry and thin.
The “Synergy Boost”: Clinical data suggests HA increases PN’s fibroblast-stimulating power by up to 20%.
Plinest Benefits
Reliable and proven features
Easy to use with a simple setup
Cost-effective for long-term use
Stable performance with minimal updates needed
Familiar interface that reduces learning time
Newest Benefits
Enhanced performance with the latest technology
Improved user experience and modern design
Advanced security and updated compliance standards
Greater flexibility and customization options
Better integration with new tools and platforms
Expanding the Family: Specialized Plinest Formulas
To be a true authority on this topic, we have to look beyond the basic “face” treatment. Mastelli has developed a full ecosystem of PN products:
Plinest Fast: A lower-density formula specifically for the delicate periorbital (eye) area. It reduces dark circles and “crepey” lids without the risk of puffiness.
Plinest Hair: Designed for the scalp, this formula stimulates hair follicles and improves scalp health, making it a natural alternative for thinning hair.
Plinest One: A larger volume syringe specifically for body treatments, like treating stretch marks or laxity on the abdomen and knees.
Better Together: Synergistic Treatment Protocols
The most exciting trend in 2026 is the “Stacking” method. Because Plinest and Newest repair the skin’s foundation, they make other treatments work better.
With Lasers: Using PN injections 2 weeks before a fractional laser treatment primes the skin for faster healing and better collagen yield.
With Microneedling: Combining PN with Radiofrequency Microneedling creates a “bio-remodelling” powerhouse that can virtually erase fine lines.
With Botox: While Botox relaxes muscles, PN improves the skin texture on top of those muscles, preventing that “shiny, thin” look sometimes associated with over-injecting.
What to Expect: Treatment and Results
The procedure is relatively quick, usually taking about 30–45 minutes including numbing time. Your doctor will use a series of micro-injections across the target area (face, neck, or hands).
You won’t look like a different person overnight. Because this is regenerative medicine, the magic happens over time. Most patients notice a “brightness” within a week, but the real structural changes typically peak after 3 sessions, spaced 3 weeks apart. Results can last anywhere from 8 to 12 months.
People Also Ask (FAQs)
1. How many sessions of Plinest or Newest do I need? For optimal results, most clinics recommend an initial loading phase of 3 sessions spaced 3 weeks apart. Maintenance is usually one session every 6-9 months to keep the “bioregenerative engine” running.
2. Is Plinest better than Rejuran? Both are polynucleotide treatments. However, Plinest is often praised for its Italian HPT purification technology (which removes all protein contaminants), while Rejuran is the Korean pioneer. Both are excellent, but Plinest is often considered “cleaner” for those with sensitive skin.
3. Can I have this if I have a fish allergy? Since the PN is derived from trout or salmon DNA, most doctors advise against it if you have a severe fish allergy, though the purification process is extremely rigorous.
4. What is the downtime? Expect “mosquito bite” bumps at the injection sites. These typically resolve within 24 hours on the face, though they may last 48 hours in thinner skin areas like the neck or under-eyes.
5. How much does a Plinest treatment cost? Prices vary by region and clinic, but generally, expect to pay between RM1,500 to RM3,500 per session. Given the long-lasting regenerative effects, many consider it a better long-term value than traditional HA boosters.
Summary: The Future of Your Skin
In an era where “natural” is the new luxury, Plinest and Newest offer a sophisticated way to age gracefully. They don’t change your face; they simply give your skin the tools to repair itself. Whether you’re battling stubborn acne scars, thinning hair, or just want that “well-rested” radiance, these polynucleotide powerhouses are the ultimate investment in your skin’s biological future.